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Clinical criteria for obstetric APS include at least one of the following pathologies: early or late gestational loss, intrauterine growth restriction, placental insufficiency, or PE ( The mechanisms of injury of aPL involve activation of the endothelium, platelets, and monocytes, and complement activation and inhibition of anticoagulant proteins, leading to the phenomena of inflammation and thrombosis

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Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase