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Moreover, OS is implicated in the dysfunction of melanocyte adhesion, caused by the ROS-mediated disruption of E-cadherin expression, thus contributing to melanocyte detachment and loss [82]
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Based on these observations, we hypothesized that an alternative pathway beyond PSMA-guided endocytosis exists for the (passive) cellular permeability of 2a , despite its high molecular weight and negative charge, delivering it to the intracellular milieu where GSH acts to release MZ1
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