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There is no controlled human efficacy data of any kind, and the only clinical test of the underlying mechanism failed: Athira Pharma's fosgonimeton (ATH-1017), a structurally distinct HGF/MET positive modulator from the same scientific lineage, missed both its primary and key secondary endpoints in the LIFT-AD Phase 2/3 trial reported in September 2024, in a primary analysis population of 312 mild-to-moderate Alzheimer's patients not taking acetylcholinesterase inhibitors (GST change -0.08, p = 0.70, over a 26-week treatment period)

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The resolutions of the final consensus maps were 2.2 Å, 2.2 Å, 2.7 Å and 3.0 Å for the CTR, AMY 1 R, AMY 2 R and AMY 3 R, respectively, determined at gold standard Fourier shell correlation (FSC) 0.143 (Fig