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NA cannot be salvaged into NAD + any longer if it is N-methylated by NNMT, so the methylation of NA impairs the abundance of free NAD + and then affects the activities of these NAD + -consuming enzymes [19]

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In conclusion, by targeting senescence, we offer a strategy that simultaneously decreases radioresistance of [non–small cell lung cancer] and the incidence of RIPF.” Not only were the fibroblasts (cells commonly found in connective tissue) more susceptible to radiation therapy treatment instead of being more resistant to it, but it also treated damage and scarring to lung tissue induced by radiation therapy